The idea is very simple: for any sequence, replace a repeated run of any nucleotide (i.e. homopolymers) by a single occurrence of that nucleotide. This means that after going through HPC the sequence AAACTGGG will yield the sequence ACTG. This simple pre-processing step, applied to all the reads and sequences to analyze, removes all indels in homopolymers, and can resolve some ambiguities (c.f. Figure 1.6). It can also remove legitimate information contained in homopolymers, but the trade-off with the reduced error rate has been deemed advantageous.
Во Франции оценили проект миссии в Ормузском проливеПолитик Филиппо раскритиковал проект военной миссии Макрона в Ормузском проливе
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